Developing Virus-Like Particles (VLPs) and Heterologous VLPs Vaccines for Epizootic Hemorrhagic Disease Virus (EHDV) Serotypes
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منابع مشابه
Filovirus-like particles as vaccines and discovery tools.
Ebola and Marburg viruses are members of the family Filoviridae, which cause severe hemorrhagic fevers in humans. Filovirus outbreaks have been sporadic, with mortality rates currently ranging from 30 to 90%. Unfortunately, there is no efficacious human therapy or vaccine available to treat disease caused by either Ebola or Marburg virus infection. Expression of the filovirus matrix protein, VP...
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Epizootic hemorrhagic disease is an important disease of cervids, especially white-tailed deer. The causative virus is widespread among wild cervids in North America, where white-tailed deer are endemic, and periodically causes serious epidemics in wild and/or captive populations. Sporadic clinical cases and outbreaks have also been reported in other cervids, cattle, bison, yaks and other anima...
متن کاملHomologous and Heterologous Protection of Nonhuman Primates by Ebola and Sudan Virus-Like Particles
Filoviruses cause hemorrhagic fever resulting in significant morbidity and mortality in humans. Several vaccine platforms that include multiple virus-vectored approaches and virus-like particles (VLPs) have shown efficacy in nonhuman primates. Previous studies have shown protection of cynomolgus macaques against homologous infection for Ebola virus (EBOV) and Marburg virus (MARV) following a th...
متن کاملVirus-like particles exhibit potential as a pan-filovirus vaccine for both Ebola and Marburg viral infections.
A safe and effective pan-filovirus vaccine is highly desirable since the filoviruses Ebola virus (EBOV) and Marburg virus (MARV) cause highly lethal disease typified by unimpeded viral replication and severe hemorrhagic fever. Previously, we showed that expression of the homologous glycoprotein (GP) and matrix protein VP40 from a single filovirus, either EBOV or MARV, resulted in formation of w...
متن کاملEvaluation of RT-PCR for detection of Sudanese serotypes of epizootic hemorrhagic disease virus serogroup
Epizootic hemorrhagic disease (EHD) is an infectious non-contagious disease of deer and cattle. At least 2 serotypes of EHD virus, designated EHDV-4 and EHDV-318, are enzootic in the Sudan. To facilitate clinical disease investigation and control of the disease a rapid diagnostic assay is urgently needed. A reverse transcriptase (RT) polymerase chain reaction (RT-PCR) protocol, previously repor...
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